Small GTPase and Terry O'Connor (rugby league)

Small GTPases (EC 3.6.5.2) are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-proteins found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and hydrolyze a guanosine triphosphate (GTP) to form guanosine diphosphate (GDP). The most well-known members are the Ras GTPases and hence they are sometimes called Ras superfamily GTPases.

A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The GDP can be then replaced by free GTP. Therefore, a G-protein can be switched on and off. GTP hydrolysis is accelerated by GTPase activating proteins (GAPs), while GTP exchange is catalyzed by Guanine nucleotide exchange factors (GEFs). Activation of a GEF typically activates its cognate G-protein, while activation of a GAP results in inactivation of the cognate G-protein. Guanosine nucleotide dissociation inhibitors (GDI) maintain small GTP-ases in the inactive state.

Small GTPases regulate a wide variety of processes in the cell, including growth, cellular differentiation, cell movement and lipid vesicle transport.

Contents 1 The Ras superfamily 2 See also 3 References 4 External links

The Ras superfamily Main article: Ras superfamily

There are more than a hundred proteins in the Ras superfamily. Based on structure, sequence and function, the Ras superfamily is divided into nine main families, each of which is further divided into subfamilies: Ras, Rho, Rab, Rap, Arf, Ran, Rheb, Rad and Rit. Miro is a recent contributor to the superfamily.

Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity.

The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as IQGAP and WASP.

The Ras family is generally responsible for cell proliferation, Rho for cell morphology, Ran for nuclear transport and Rab and Arf for vesicle transport. See also GTP-binding protein regulators

Terry O'Connor (rugby league) and Small GTPase

Terry O'Connor (born 13 October 1972) is an English former professional rugby league footballer of the 1990s and 2000s. A Great Britain, England and Ireland international and Lancashire representative Prop or Second-row forward, he played his club rugby for English clubs Salford, Wigan and Widnes.

Contents 1 Biography 1.1 Professional playing career 1.1.1 Salford 1.1.2 Wigan 1.1.3 Widnes 1.2 Post playing 2 References 3 External links

Biography

Born in Widnes, Lancashire, O'Connor was picked up from local Widnes side St Marie's after also playing for Widnes Tigers. He was a former BARLA international and toured New Zealand with them in 1991. Also on the tour was Darren Fleary, Paul Anderson and Barrie McDermott, all of them went on to gain full international honours. Professional playing career Salford

In 1990 Terry signed for Salford, and played for them for three years. He had the opportunity of signing for Wigan, St Helens, Warrington, Leeds and Bradford, but chose Salford as his childhood hero Steve O'Neill was part of the coaching team, along with Kevin Tamati. He was awarded Salford's young player of the year in 1991. He played in the Regal Trophy quarter final against Wigan at the Willows and was awarded the Man-of-the-Match. He joined Wigan in 1994 for a Salford record transfer fee of £95,000 and New Zealand International Sam Panapa. Salford also got a further £10,000 when Terry played for Great Britain. Wigan

Whilst at Wigan he went on to win the Challenge Cup, Charity Shield, Regal Trophy, Premiership, Championship. He debuted for the Great Britain team in 1996 on the South Pacific tour. O'Connor played for Wigan at prop forward in their 1998 Super League Grand Final victory against Leeds. O'Connor played for the Wigan Warriors at prop forward in their 2000 Super League Grand Final loss against St Helens RLFC.

O'Connor played for the Wigan Warriors at prop forward in their 2001 Super League Grand Final loss to the Bradford Bulls.

O'Connor played for the Wigan Warriors in the 2003 Super League Grand Final which was lost to the Bradford Bulls.

In his time at Wigan, O'Connor played 317 first grade game and was voted into the Wigan and Super League team of the decade. He was a mainstay of the Wigan pack for a decade and enjoyed a testimonial in 2004 for his services to Wigan. Terry donated part of his testimonial money to under privileged children, which allowed them to go on holiday to Euro-Disney back in November 2004. In the history of Wigan RLFC, only 27 players have worn the Cherry and White top more than him.

Terry was also named in the SL dream team on 4 occasions in 1996, 2000, 2001, 2002 and was also named in the SL team of the decade. O'Connor was also the 1st prop forward to be named on 4 occasions in the dream team.

Widnes

O'Connor joined his hometown club Widnes at the end of the 2004 season. He captained the side in 2005 but with the introduction of Catalans Dragons to Super League in 2006 meant that the team who finished 11th were relegated and it was unfortunate but Widnes finished 11th ahead of Leigh. Terry played on for one more year in the National League for Widnes and got to play his last competitive game in the Grand Final only to be beaten by Hull Kingston Rovers. He was also joined in his final year by his good friend Barrie McDermott they both retired in 2006.

O'Connor went on to represent Ireland at the 2000 Rugby League World Cup and went on to captain the Irish on numerous occasion. The side earned fabulous reviews under the guidance of Terry and his best friend Barrie McDermott. O'Connor also represented Lancashire in the Origin Series in 2001 and 2002 and never lost against arch rivals Yorkshire. He was awarded the Roy Powell medal for his performance in the 2001 series. O'Connor retired from Great Britain in 2002 with 15 caps.

On 25 March 2004 O'Connor was one of six footballers inducted into Rugby League Ireland's inaugural Hall of Fame at the Rugby League Heritage Centre in Huddersfield. Post playing Terry O'Connor on duty with Ireland at the 2008 Rugby League World Cup.

After retiring from playing the game in 2006 O'Connor took on the role of Sporting Director at Widnes along with his role at Sky Sports, appearing in light-hearted features with Barrie McDermott as well as serving as a pundit for the coverage of lower-league games.

O'Connor is still heavily involved in charity work for former players and local under privileged Children
106/766 103 104 105 107 108 109 keramik